3rd MMCS: Shaping Medicinal Chemistry for the New Decade
16–18 Feb 2022, Rome, Italy
Drug Discovery, SARS-CoV-2, Drug Design, Machine Learning, Medicinal Chemistry
- Go to the Sessions
- Event Details
Welcome from the Chairs
It is with great pleasure that we announce the 3rd Molecules Medicinal Chemistry Symposium—Shaping Medicinal Chemistry for the New Decade (MMCS2022), to be held in Rome, Italy, from 16 to 18 February 2022.
The conference is co-organized by the Sapienza University of Rome, Department of Drug Chemistry and Technology, and MDPI, the publisher of the open-access journal Molecules. The conference is a follow-up to the successful 2nd Molecules Medicinal Chemistry Symposium—Facing Novel Challenges in Drug Discovery (MMCS2019), held in May 2019 in Barcelona, Spain. This turned out to be a very fruitful forum that delved into numerous topics. The excellent atmosphere was created by the presence of more than 190 attendees from 30 countries.
Encouraged by the great success of the MMCS2019, the three-day MMCS2022 will continue to address a large audience and a wide variety of current medicinal chemistry topics. The MMCS2022 will be organized into a number of thematic sessions on the medicinal chemistry of particularly challenging diseases, novel and revisited drug discovery approaches, and medicinal chemistry stories about recently implemented projects in areas not covered in the other sessions—target and hit identification, hit-to-lead optimization, the tuning of physicochemical and pharmacokinetic properties, preclinical and clinical development, etc.
In each session, two prominent and inspiring keynote speakers will share the program with a number of oral communications selected from among the contributions submitted by young researchers. The program will be complemented by poster presentations and social events.
We look forward to seeing you in Rome.
Prof. Rino Ragno
Editor of the Medicinal Chemistry Section of Molecules
Prof. Diego Muñoz-Torrero
Editor-in-Chief of the Medicinal Chemistry Section of Molecules
Ms. Lucy Chai
Dr. Ana Sanchis
Mr. Pablo Velázquez
Email: [email protected]
Local Organizing Committee
Prof. Dr. Rossella Fioravanti
Prof. Dr. Sergio Valente
Prof. Dr. Dante Rotili
Dr. Manuela Sabatino
Dr. Lorenzo Antonini
Dr. Eleonora Proia
Prof. Dr. Rino Ragno
Professor Rino Ragno
Sapienza University of Rome, Italy
Rino Ragno is an associate professor at the Drug Chemistry and Technology Department - Pharmacy and Medicine Faculty, Sapienza University of Rome.He started as medicinal chemist doing synthesis for about 10 years then as Italian NIH fellow spent two years in the Prof. G. R. Marshall’s lab at Washington University in St. Louis. In 2017 he achieved the national abilitation as Full Professor in medicinal chemistry. Prof. Rino Ragno is co-author of more than 120 peer reviewed artcles on interantional journals at high impact factor.
Professor Diego Muñoz-Torrero
University of Barcelona, Spain
Prof. Diego Muñoz-Torrero is Associate Professor of Organic and Medicinal Chemistry at the Faculty of Pharmacy and Food Sciences, University of Barcelona (UB). He is Head of the Laboratory of Pharmaceutical Chemistry and belongs to the Governing Board of the Institute of Biomedicine (IBUB). He belongs to the editorial advisory board of several medicinal chemistry journals and serves as the Editor-in-Chief of the Medicinal Chemistry Section of the MDPI journal Molecules.
Dr. Jóhannes Reynisson FRSC
School of Pharmacy and Bioengineering, Keele University, UK
Prof. Dr. Florenci V. González
Universitat Jaume I, Spain
Prof. Dr. Maria Emília Sousa
Laboratory of Organic and Pharmaceutical Chemistry (LQOF), University of Porto, Portugal,
Interdisciplinary Centre of Marine and Environmental Research (CIIMAR), Portugal.
Prof. Dr. Anne Roivainen
Turku PET Centre, University of Turku and Turku University Hospital, Finland
Prof. Dr. Giuseppe Manfroni
Dipartimento di Science Farmaceutiche, Università degli Studi di Perugia, Italy
Prof. Dr. Mariana Spetea
University of Innsbruck, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck (CMBI), Austria.
Prof. Dr. Jorge Salvador
Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Coimbra, Portugal
Prof. Dr. Mariarosaria Miloso
Experimental Neurology Unit, School of Medicine and Surgery, Milan Center for Neuroscience, University of Milano-Bicocca, Italy
Prof. Dr. Massimo Bertinaria
Department of Drug Science and Technology, University of Turin, Italy
Prof. Dr. Helen Osborn
School of Pharmacy, University of Reading, UK
Prof. Dr. Josef Jampilek
Faculty of Natural Sciences, Comenius University in Bratislava, Slovakia
Prof. Dr. Bernard Maigret
LORIA Institute, CNRS - INRIA - Lorraine University, France
Dr. Dante Rotili
Department of Chemistry and Technology of Drugs, Sapienza University of Rome, Italy
Prof. Dr. Kelly Chibale
Drug Discovery and Development (H3D) Centre, University of Cape Town (UCT), South Africa
Combating Multi-Drug Resistance in Tuberculosis: strategies underpinned by Medicinal Chemistry
Prof Kelly Chibale is the Founder and Director of H3D. He is also the founding Director of the South African Medical Research Council Drug Discovery and Development Research Unit at UCT. He is the Neville Isdell Chair in African-centric Drug Discovery & Development, a Professor of Organic Chemistry, and a Tier 1 South Africa Research Chair in Drug Discovery.
Prof. Dr. Janine Cossy
Molecular Chemistry and Catalysis, ESPCI Paris, France
Synthetic Approach to a Natural Antitumor Agent
Janine Cossy graduated from Reims University and after a postdoctoral stay in the US, she returned to Reims where she became, in 1990, Director of Research at the CNRS. In the same year, she moved to Paris where she was appointed Professor at the ESPCI Paris. J. Cossy’s research interests focus on the synthesis of natural and/or bioactive compounds and on the development of synthetic methods. Her research efforts have resulted in more than 540 publications and 18 patents. In 2017, She was elected at the French Academy of sciences.
Prof. Dr. Svetlana B. Tsogoeva
Organic Chemistry Chair I and Interdisciplinary Center for Molecular Materials (ICMM), Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany
Multi-Step Domino Reactions: Facile Access to Antiviral and Antimalarial Agents
Svetlana B. Tsogoeva graduated with Distinction from St. Petersburg State University, where she completed her doctoral thesis in 1998. Then, she moved to the Johann Wolfgang Goethe University for postdoctoral research. In 2000 she joined the Degussa AG as a research scientist. In 2002 she was appointed a first junior professor in Germany at the Georg-August-University of Göttingen. Since 2007 she has been Professor of Organic Chemistry at the Friedrich-Alexander University of Erlangen-Nürnberg.
Prof. Dr. Maria Laura Bolognesi
Dipartimento di Farmacia e Biotecnologie, Università di Bologna, Italy
Maria Laura Bolognesi is Professor of Medicinal Chemistry, Coordinator of the Biotechnological, Biocomputational, Pharmaceutical and Pharmacological Sciences PhD Program at the University of Bologna. She also serves as Rector Delegate for International Relations to Latin America. Her research is concerned with the design, synthesis, and biological investigation of small molecules in the neurodegenerative and neglected tropical disease therapeutic areas. She has a track record of more than 175 publications in high-ranked scientific journals, including patents and patent applications, and numerous invited talks worldwide. She was awarded a Distinguished Visiting Professor Fellowship at the Complutense University of Madrid in 2009, a PVE Fellowship at the University of Brasilia in 2014 and Professeur Invité at Université Caen Normandie in 2018. She is also an Associate Editor of Journal of Medicinal Chemistry and serves in the Advisory Board of the European Federation of Medicinal Chemistry.
Prof. Dr. Olalla Vázquez
Philipps-Universität Marburg, Germany
Olalla Vázquez graduated with Honours from the University of Santiago de Compostela, where she completed her PhD under the supervision of Prof. Mascareñas. As PhD student, she visited the labs of Prof. Verdine and Prof. Seitz. Afterwards, she returned to Berlin as Marie Curie postdoctoral fellow. In 2014 she was appointed as Assistant Professor (W1) at the University of Marburg to manage the newborn Chemical Biology division. In April 2020, Olalla successfully passed her tenure evaluation, and was promoted to Associate Professor (W2) in January 2021. Innovative optochemical tools and epigenetics are the core of her research.
Prof. Dr. Mauro Maccarrone
Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila (Italy)
Plant-Derived & Endogenous Cannabinoids: Different in Nature
Mauro Maccarrone, Dr. Enzymology and Bio-Organic Chemistry, is Professor and Chair of Biochemistry at the Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila (Italy). He is also Head of the Lipid Neurochemistry Unit at the European Center for Brain Research – IRCCS Santa Lucia Foundation, Rome (Italy). Chair of the 2015 Gordon Research Conference on “Cannabinoid Function in the CNS”. Visiting Professor at Leiden University in 2017, and at University of Cambridge in 2019. He authored more than 500 full papers, and is listed among the Top Italian Scientists. For his research activity he has received, among other prizes, the “2020 Tu Youyou Award”.
Prof. Dr. Antonello Mai
Sapienza University of Rome, Roma, Italy
Antonello Mai is a Full Professor in the Department of Drug Chemistry and Technologies, in Sapienza University of Rome. He is a professor of the following courses at the Faculty of Pharmacy and Medicine of Sapienza University of Rome involving Medicinal Chemistry: Medicinal Chemistry 1, Medicinal Chemistry 2, Medicinal Chemistry 3, Medicinal Chemistry and Toxicology Analysis, Pharmaceutical Biotechnology. He has great expertise in 1) organic synthesis; 2) synthesis of new potential bio-active compounds, particularly in the field of epigenetics (inhibitors of DNMTs, HDACs [unselective and class-selective], HATs, sirtuins, PRMTs, HKMTs, and HDs), anticancer agents, antiviral agents (anti-human picornavirus compounds (disoxaril analogues), and anti-HIV-1 compounds belonging to the non-nucleoside reverse transcriptase inhibitor classes (DABOs, S-DABOs, DATNOs, F2-S-DABOs, Amino-DABOs), antibacterial (oxacine analogues), antimycobacterial (oxacine and U-100480 analogues) and antifungal (trichostatin A, pyrrolnitrin, and bifonazole analogues) agents, and CNS agents (pyrrolobenzodiazepines active as analgesic, antidepressant and nootropic compounds); 3) development of new methodology for the synthesis of heterocycles; 4) analysis and purification of organic mixtures; 5) study and characterization of organic molecules.
Prof. Dr. Gabriele Cruciani
Chemistry Department, University of Perugia, Italy
Gabriele Cruciani is full professor of Organic Chemistry and Cheminformatics at the University of Perugia, Italy. Prof. Cruciani is the scientific director of Molecular Discovery company based in London, of Molecular Horizon based in Perugia, Italy, and of Montelino Therapeutics based in Boston, USA. He’s also the director of the human Cytochrome Consortium Initiative (a consortium of seven pharmaceutical companies collaborating to address metabolism issues in predictive human metabolism) and a member of the technical scientific advisory board of several pharmaceutical companies. In 2001 he got the Corvin Hansch Award from the Molecular Modeling Society in USA for his work on QSAR and Molecular Modeling, in 2005 he got the Research Award from Società Chimica Italiana, Organic Chemistry Division, and in 2009 he was the recipient of the Novartis Research Award. In 2014 he was the recipient of the gold medal Angelo Mangini award from Italian Chemical Society and finally in 2015 he was the recipient of the gold medal Herman Wold Award from Swedish Chemical Society. Prof. Cruciani made significant contributions to the field of ADME and computer-aided drug design, due to his over two decades of software production for data mining and drug discovery experience, focused on drug informatics, cheminformatics, small-molecule and target informatics, and virtual screening. He obtained several EU grants and Italian research grants, plus a number of support grants from pharmaceutical companies. Cruciani is included in the Top Italian Scientists list.
Prof. Dr. Manfred Jung
University of Freiburg, Germany
Chemical Epigenetics - targeting reversible histone acetylation and methylation
Manfred Jung is an expert in the Medicinal Chemistry and Chemical Biology of epigenetic inhibitors and probes. His research groups works on synthesis, assay development and screening for epigenetic modifiers. Manfred did his PhD at the University of Marburg in 1993, then worked as a postdoc with T. Durst at the University of Ottawa. From 1994 to 2003 he was a junior group leader at the University of Münster From 2003 on he was a Professor of Pharmaceutical Chemistry at the University of Freiburg and since 2011 he is Full Professor there. He was appointed twice as Senior Fellow at the Freiburg Institute of Advanced Studies (FRIAS) and is the co-speaker of the Collaborative Research Centre “Medical Epigenetics” in Freiburg.
The registration fee includes attendance of all conference sessions, morning/afternoon coffee breaks and lunches, conference bag and program book.
Participation to the conference is considered final only once the registration fees have been paid. The number of participants is limited: once the number of paid registrations reaches the maximum number of participants, unpaid registrations will be cancelled.
Please note that, in order to finalize the scientific program in due time, at least one registration by anyone of the authors, denoted as Covering Author, is required to cover the presentation and publication of any accepted abstract. Covering Author registration deadline is 14 January 2022. Your abstract will be withdrawn if your registration is not complete by this date.
When registering, please provide us with your institutional email address. This will accelerate the registration process. If you are registering several people under the same registration, please do not use the same email address for each person, but their individual institutional email addresses. Thank you for your understanding.
Certificate of Attendance: Upon request, the participants of the event will receive an electronic Certificate of Attendance by email once the event is concluded.
|Academic||400.00 EUR||500.00 EUR||600.00 EUR|
|Academics from Sapienza University of Rome||320.00 EUR||400.00 EUR||480.00 EUR|
|Members of the Department of Drug Chemistry and Technologies (Sapienza University of Rome)||280.00 EUR||350.00 EUR||420.00 EUR||
Scanned accreditation document as a member of the department is required.
|Student||250.00 EUR||300.00 EUR||350.00 EUR||
Scanned copy or photograph of your current student ID is required.
|Guest Editors/Board Members of Molecules or Media Partner journals||300.00 EUR||400.00 EUR||500.00 EUR|
|Non-Academic||650.00 EUR||750.00 EUR||850.00 EUR|
|Invited Speakers and MDPI Guests||Free||Free||Free|
Cancellation of paid registration is possible under the terms listed below:
> 2 months before the conference
Full refund but 60 EUR are retained for administration
> 1 month before the conference
Refund 50% of the applying fees
> 2 weeks before the conference
Refund 25% of the applying fees
< 2 weeks before the conference
Visa Support Letters
- Applicants must have paid for registration and submitted an abstract in order to get a letter of support.
- Applicants must provide us with a scan of their valid in date passport that contains a photo of them.
- Applicants must provide us with an academic CV, two references from their institution (contact information including institutional email and phone) and a letter of support from their institution to confirm that they support the delegate attending the meeting.
- This must be carried in good time before the meeting, “last minute” requests will not be processed.
We will endeavour to present the program advertised. However, in the unlikely event that MDPI shall deem it necessary to cancel the conference, all pre-paid registration fees will be reimbursed. MDPI shall not be liable for reimbursing the cost of travel or accommodation arrangements made by individual delegates. Tours run by third parties may be subject to cancellation or alteration.
Beware of Unauthorized Registration and Hotel Solicitations
Note that Sciforum is the only official registration platform to register to MMCS 2022, and that we are not associated with any hotel agency. While other hotel resellers and travel agencies may contact you with offers for your trip, they are not endorsed by or affiliated with MMCS 2022 or Sciforum. Beware that entering into financial agreements with non-endorsed companies can have costly consequences.
The organizers do not accept liability for personal accident, loss, or damage to private property incurred as a result of participation in the MMCS 2022. Delegates are advised to arrange appropriate insurance to cover travel, cancellation costs, medical, and theft or damage of belongings.
Wire transfer, Credit card
Instructions for Authors
The 3rd MMCS: Shaping Medicinal Chemistry for the New Decade will accept abstracts only. The accepted abstracts will be available online on Sciforum.net during and after the conference.
To register for the conference, please follow this link.
To present your research at the event
Create an account on Sciforum if you do not have one, then click on ‘New Submission’ on the upper-right corner of the window, or by clicking on ‘Submit Abstract’ at the top of this webpage. Indicate what thematic area is best suited for your research.
- Submit an abstract in English (minimum 150 words and maximum 300 words). The deadline to submit your abstract is 20 October 2021. You will be notified by 19 November 2021 about the acceptance for poster or oral presentation.
- Upon submission, you can select if you wish to also be considered for oral presentation. Following assessment by the Chairs, you will be notified by 19 November 2021 in a separate email whether your contribution has been accepted for oral presentation.
- Please note that, in order to finalize the scientific program in due time, at least one registration by any of the authors, denoted as Covering Author, is required to cover the presentation and publication of any accepted abstract. Covering Author registration deadline is 14 January 2022. Your abstract will be withdrawn if your registration is not complete by this date.
Short talks will be 15 min long including questions (12+3 Q&A). The typical presentation should be up to 10–12-minute talk.
All presentations must be uploaded in advance. Please bring your presentation to the registration desk at least 30 min before the start of your session, or at the end of the previous day for the early morning sessions. A technician will be available to assist you.
Information about the poster sessions will be updated later on. A number of posters will be selected by the Scientific Committee for the Best Poster Award and they will be identified with a sign on their board. In addition, these posters will be presented with a 3-min Flash Presentation during a special session on the first day of the conference.
- All accepted abstracts will be available online in Open Access form on Sciforum.net.
- Participants of this conference are encouraged to contribute with a full manuscript to our one Special Issue related to the conference in the journal Molecules. The conference participants will be granted a 20% discount on the publishing fees.
- Molecules is indexed by the Science Citation Index Expanded (Web of Science), MEDLINE (PubMed) and other databases, and has an Impact Factor of 4.411 (2020).
The preliminary program of 3rd MMCS: Shaping Medicinal Chemistry for the New Decade is now available.
|Wednesday 16 February 2022||Thursday 17 February 2022||Friday 18 February 2022|
Session 1: Molecules against drug resistant microorganisms and SARS-CoV-2
Session 3: Machine Learning in Drug Design
Session 5: Multitarget Drug Discovery
Session 1: Part II
Session 3: Part II
Session 5: Part II
|Lunch||Lunch & Poster Session A||Lunch & Poster Session B|
Session 2: Targeting Proteins for Degradation: PROTACS, PHOTACS, LYTACs, and molecular glues
Session 4: Natural Compounds in Drug Discovery
|Session 6: Medicinal Chemistry Tales|
Session 2: Part II
|Session 6: Part II|
Flash Posters Presentations
& Closing Remarks
Venue, Travel and Accommodation
Rome has been one of the world's most visited cities for the past two millennia. In the Roman times, Rome was the centre and the most powerful city of Western Civilization, ruling all the Mediterranean, Northern Africa, England and parts of the Middle East. Afterwards, it became one of the most important cities in Christianity, since the pope, the head of the Roman Catholic Church, resided and still lives in Rome. It became a worldwide centre of pilgrimage, and later in the Renaissance, as the city became a major European capital of the arts, education, philosophy and trade, it became an important crossroads for bankers, artists and other people in general.
Most popular tourist attractions
Rome's two most popular tourist destinations are the Vatican Museums (with over 4.2 million tourists per year, making them the world's 37th most visited destination) and the Colosseum (with around 4 million tourists a year, making it the world's 39th most popular tourist destination). Other popular sites include St Peter's Basilica, the Forum Romanum, the Pantheon, the Trevi Fountain, the Spanish Steps, Via Condotti, Via Veneto, the Capitoline Museums, the Villa Borghese gardens, the Villa Giulia, Piazza Navona, the Basilica di Santa Maria Maggiore, the Archbasilica of Saint John Lateran, the Piazza del Popolo, the Castel Sant'Angelo, the Campo de' Fiori, the Quirinal Palace, the Lateran Palace and the Palazzo Barberini, to name a few.
Sapienza University of Rome
The Sapienza University of Rome is a research university that is located in Rome, Italy. Formally known as Università degli Studi di Roma "La Sapienza", it is one of the largest European universities by enrollments and one of the oldest in history, founded in 1303. The University is one of the most prestigious Italian universities and in the world, commonly ranking first in national rankings and in Southern Europe. In 2018, 2019 and 2021 it ranked first in the world for classics and ancient history.
Address: Piazzale Aldo Moro, 5, 00185 Roma RM, Italy (Google maps)
You can find a map of Sapienza in here: https://www.uniroma1.it/sites
Rome has two international airports, but the main one is Leonardo da Vinci International Airport in Fiumicino (FCO). The airport is located at 32 km from Rome city centre and is well connected to airport hubs in Europe and several locations around the world. For more information about the airport and flights, please visit the official website www.adr.it
Once you get to the airport, you have several options to reach the city centre and/or the conference venue.
To the city centre:
- By shuttle bus: The 'Leonardo da Vinci' airport can be reached by several bus lines. Information on timetables, routes and ticket prices can be found on the websites of the various companies and here.
- By train: Trenitalia railway services (https://www.trenitalia.com).
The Leonardo express, non-stop service dedicated exclusively to airport passengers to/from Roma Termini with departures every 15 minutes and travel time of 32 minutes.
The FL1 regional line trains from/to other Rome stations, with departures every 15 minutes on working days and every 30 minutes on weekends and holidays.
- By taxi: Taxi service is available at Terminal 1 and Terminal 3 Arrival areas. Authorized Taxi vehicles are white with a “TAXI” sign on the roof. The symbol of the Municipality of reference is fixed to the front doors and the license number is on the doors, on the back and inside the vehicle. You can find information on different fixed fares in here.
Coronavirus, advice from the Sapienza University
Italy applies health-related restriction measures to incoming travellers, which may vary depending on their country of origin. You can find actualized information on the following website: http://www.italia.it/en/useful-info/covid-19-updates
GOING TO SAPIENZA UNIVERSITY
In order to recognize the works presented during the conference in the format of posters and presentations, two awards will be offered to our conference participants, which will be announced during the Award Ceremony on the last day of the conference.
Selected by the Scientific Committee after evaluation of all selected talks presented during the conference.
Selected by the Scientific Committee after an evaluation of the posters received.